获奖作品基本信息
| 年份 | 2018 |
| 学科 | 植物科学 PLANT SCIENCES |
| 学校 | No. 2 High School of East China Normal University |
| 国家/州 | China |
获奖作品名称
Crude Extraction of Amana edulis Induces Liver Cancer Apoptosis
获奖作品摘要
HCC has become the fastest-rising cause of cancer-related death. A novel therapeutic approach for treatment is warranted. The goal of this study is to find effective components from Chinese herbal medicines, which is an important alternative source of anti-cancer medicines. To this end, six different herbs were selected from various traditional literatures. Then, Soxhlet extractor was used to distill the strong polar and weak polar components of each herb. The inhibitive effect of each component was determined using liver cancer cells BEL7404. From total of 12 extractions, it was found that the combined crude lysate of Amana Edulis from water and ethanol system had the best efficacy. At the concentration of 0.1 mg/mL, this component has a highest inhibition rate up to 70%. To investigate the potential molecular reasons, we observed that the component can significantly induce the liver cancer cells apoptosis and retard the cell reproduction at G2/M stage. Verification experiments showed that this component also has apparent inhibitive effects on other liver cancer cells, such as HepG2 and Huh7. On the other hand, it has less effectiveness on another cell line HepaRG, which retains many characteristics of primary human hepatocytes. The results suggested that there might be highly efficient anti-hepatoma ingredient in the water and ethanol extraction of Amana Edulis. The pure substances remain to be isolated and further research on their targets are required.
Keywords: Chinese herbal medicine; Amana edulis; Apoptosis; Liver cancer
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高中生科研竞赛 英特尔 Intel ISEF 简介
英特尔国际科学与工程大奖赛，简称 "ISEF"，由美国 Society for Science and the Public（科学和公共服务协会）主办，英特尔公司冠名赞助，是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的竞赛学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学竞赛的“世界杯”之美誉，旨在鼓励学生团队协作，开拓创新，长期专一深入地研究自己感兴趣的课题。
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学科简介：植物科学 PLANT SCIENCES
Studies of plants and how they live, including structure, physiology, development, and classification. Includes plant cultivation, development, ecology, genetics and plant breeding, pathology, physiology, systematics and evolution.
Subcategories:
Agriculture and Agronomy (AGR): Application of the various soil and plant sciences to soil management and agricultural and horticultural crop production. Includes biological and chemical controls of pests, hydroponics, fertilizers and supplements.
Ecology (ECO): The study of interactions and relationships among plants, and plants and animals, with their environment.
Genetics and Breeding (GEN): The study of organismic and population genetics of plants. The application of plant genetics and biotechnology to crop improvement. This includes genetically modified crops.
Growth and Development (DEV): The study of a plant from earliest stages through germination and into later life. This includes cellular and molecular aspects of development and environmental effects, natural or manmade, on development and growth.
Pathology (PAT): The study of plant disease states, and their causes, processes, and consequences. This includes effects of parasites or disease-causing microbes.
Plant Physiology (PHY): The study of functions in plants and plant cells. This includes cellular mechanisms such as photosynthesis and transpiration, and how plant processes are affected by environmental factors or natural variations.
Systematics and Evolution (SYS): The study of classification of organisms and their evolutionary relationships. This includes morphological, biochemical, genetic, and modeled systems.
Other (OTH): Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.
